{"id":53904,"date":"2023-05-31T00:36:13","date_gmt":"2023-05-31T00:36:13","guid":{"rendered":"https:\/\/www.aiopenmind.it\/ArtificialIntelligence\/?p=53904"},"modified":"2023-05-31T00:37:28","modified_gmt":"2023-05-31T00:37:28","slug":"scoperta-unica-nel-suo-genere-il-deep-learning-rivoluziona-la-ricerca-di-antibiotici-contro-acinetobacter-baumannii","status":"publish","type":"post","link":"https:\/\/www.aiopenmind.it\/ArtificialIntelligence\/scoperta-unica-nel-suo-genere-il-deep-learning-rivoluziona-la-ricerca-di-antibiotici-contro-acinetobacter-baumannii\/","title":{"rendered":"Scoperta unica nel suo genere: il deep learning rivoluziona la ricerca di antibiotici contro Acinetobacter baumannii"},"content":{"rendered":"\n

Scoperta guidata dal deep learning di un antibiotico<\/a> mirato ad Acinetobacter baumannii Acinetobacter baumannii \u00e8 un patogeno Gram-negativo nosocomiale che spesso mostra resistenza multidrug. <\/p>\n\n\n\n

Scoprire nuovi antibiotici contro A. baumannii si \u00e8 dimostrato una sfida attraverso approcci di screening convenzionali. Fortunatamente, i metodi di machine learning consentono l’esplorazione rapida dello spazio chimico, aumentando la probabilit\u00e0 di scoprire nuove molecole antibatteriche. <\/p>\n\n\n\n

“Qui abbiamo selezionato circa 7.500 molecole per quelle che inibivano la crescita di A. baumannii in vitro. Abbiamo addestrato una rete neurale con questo dataset di inibizione della crescita e abbiamo effettuato predizioni in silico per molecole strutturalmente nuove con attivit\u00e0 contro A. baumannii. Attraverso questo approccio, abbiamo scoperto abaucin, un composto antibatterico con attivit\u00e0 a spettro ristretto contro A. baumannii. Ulteriori indagini hanno rivelato che abaucin perturba il traffico delle lipoproteine attraverso un meccanismo che coinvolge LolE. Inoltre, abaucin \u00e8 in grado di controllare un’infezione da A. baumannii in un modello.”<\/p>\n\n\n\n

Questo lavoro mette in luce l’utilit\u00e0 del machine learning nella scoperta di antibiotici e descrive un promettente candidato con attivit\u00e0 mirata contro un patogeno Gram-negativo complesso.<\/p>\n","protected":false},"excerpt":{"rendered":"

Scoperta guidata dal deep learning di un antibiotico mirato ad Acinetobacter baumannii Acinetobacter baumannii \u00e8 un patogeno Gram-negativo nosocomiale che spesso mostra resistenza multidrug. Scoprire nuovi antibiotici contro A. baumannii si \u00e8 dimostrato una sfida attraverso approcci di screening convenzionali. Fortunatamente, i metodi di machine learning consentono l’esplorazione rapida dello spazio chimico, aumentando la probabilit\u00e0 […]<\/p>\n","protected":false},"author":1,"featured_media":53905,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"footnotes":""},"categories":[51],"tags":[96],"class_list":["post-53904","post","type-post","status-publish","format-standard","has-post-thumbnail","category-newstecneaiopenmind","tag-medicina"],"acf":[],"yoast_head":"\nScoperta unica nel suo genere: il deep learning rivoluziona la ricerca di antibiotici contro Acinetobacter baumannii — AIopenmind<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.aiopenmind.it\/ArtificialIntelligence\/scoperta-unica-nel-suo-genere-il-deep-learning-rivoluziona-la-ricerca-di-antibiotici-contro-acinetobacter-baumannii\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scoperta unica nel suo genere: il deep learning rivoluziona la ricerca di antibiotici contro Acinetobacter baumannii — AIopenmind\" \/>\n<meta property=\"og:description\" content=\"Scoperta guidata dal deep learning di un antibiotico mirato ad Acinetobacter baumannii Acinetobacter baumannii \u00e8 un patogeno Gram-negativo nosocomiale che spesso mostra resistenza multidrug. 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